J.Jpn. Surg. Soc.. 56(10): 1275-1291, 1956
STUDIE ON THE RIBOFLAVIN METABOLISM IN THE ACUTE SUPPURATIVE INFLAMMATION
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2nd Surgical Department, Nagoya University School of Medicine (Director: H. Imanaga) Kanzi KUBO |
1. As the load test of riboflavin for the purpose of clinical use, the riboflavin excreted in urine during 2 hours was assayed following the intra-venous injection of 1 mg. of free riboflavin after an overnight fasting.
2. By this load test, excretion ratio of healthy persons was 24.3±9.4%.
3. In the acute suppurative inflammation especially in severe cases, the excretion ratio was eIevated, sometimes upto 40% or 50%. And statistically significant differences were ascertained among the three groups examined ;
1) acute suppurative inflammation, 2) cold abscess, and 3) healthy persons.
4. ln healthy persons, major amount of injected riboflabin was excreted in urine during 2 hours following intravenous injection of 1 mg. of free riboflavin, and very little amount of riboflavin was excreted after 4 or 6 hours. But some cases of the acute suppurative inflammation, having high excretion ratio, excreted more in urine even aftter 4 or 6 hours. This may be assumed to express feature of depressed utilization of riboflavin.
5. The excretion ratio of the patients with acute suppurative inflammation indicated to change corresponding with clinical conditions of the case.
6. In the cases of acute suppurative inflammation showing high excretion ratio, the liver function was often impaired; also the sedimentation rate of erythrocytes was accelerated.
7. The excretion of riboflavin, in the cases of acute suppurative inflammation with high excretion ratio, was found to become lower by the previous administration of ACTH and cortisone.
8. Total amount of urinary riboflavin of the patients with acute suppurative inflammation was assayed for 24 hours daily. The results were not always similiar, but some cases showed the highest increase of urinary riboflavin at the time when the inflammation was the severest.
9. Riboflavin in organs of the rats, suffering from the experimentaI inflammation, was assayed in comparison with untreated rats and also with the rats which were injected broth only. The following results were obtained: Liver and kidney riboflavin showed the decrease in total amounts, reduction in the flavin adenine dinucleotide ratio and increase in the flavin mononucleotide ratio, intestinal free riboflavin was increased.
From the above mentioned, in the acute suppurative inflammation, the utilization of riboflavin is disturbed, and hyporiboflavinosis exists. And these conditions seem to have close connection with the liver function, protein metabolism, reticulo-endothelial function, pituitary-adrenocortical function, the other vitamin metabolism.
(author's abstract)
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