[
Abstract]
[
Full Text PDF] （in Japanese / 1246KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 83(11): 1331-1343, 1982
Original article
A NEW TREATMENT OF POSTISCHEMIC ACUTE RENAL FAILURE WITH ATP-MgCl2 ADMINISTRATION
The effect of ATP-MgCl
2 on the recovery of renal functions and on the reversal of renal cellular edema following renal ischemia was investigated. The bilateral renal ischemia was produced for 90 minutes in mongrel dogs. Immediately after the release of ischemia, ATP-MgCl
2 (50
μmoles/Kg) or saline was given intravenously. Administration of ATP-MgCl2 prevented the elevation of serum creatinine, BUN and the F
ENa significantly during the postischemic period. Both the changes in Na, K and cellular water contents of renal tissues, and the ultrastructural analysis of glomerular endothelial thickness and interstitial cellular circularity revealed that ATP-MgCl
2 ischemically induced renal cellular edema. Renal cellular ATP level was 0.74±0.03μmoles/g tissue in ATP-MgCl
2 treated and 0.51±0.01 in controls (mean±S.E., p＜0.001), indicating that renal cellular energy metabolism was improved with ATP-MgCl
2. These results indicate ATP-MgCl
2 administration has a salutary effect on the recovery of kidney function and on the reversal of renal cellular edema through the provision of energy directly to the renal cells.
Six patients with acute renal failure were treated with ATP-MgCl
2 (23-56
μmoles/kg) and they all survived. Therefore we concluded that ATP-MgCl
2 administration was effective for the treatment of postischemic acute renal failure.
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