J.Jpn. Surg. Soc.. 62(1): 16-23, 1961
FLUCTUATIONS OF AMINO ACIDS IN THE COURSE OF ILEUS SHOCK : REPORT II.
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Department of Surgery, Nihon Medical School (Director: Prof. Saburo MATSUKURA) Kiyoshi OKAZAKI |
1) During ileus shock the content of plasma amino acid nitrogen in the blood of the femoral, portal and hepa tic veins is strikingly elevated so as to produce a condition usually called aminoacidemia.
2) Under normal conditions, the blood from the femoral, portal and hepatic veins contains such amino acids as asparaginic acid, glutamic acid, serine, glycine, cystine, threonine, glutamine, leucine, isoleucine, tryptophan, methionine and alanine.
3) In ileus shock, however, while such amino acids as glycine, leucine and isoleucine are not only increased in the blood of the femoral, portal and hepatic veins, but also such amino acids as lysine, argine, proline, valine, histidine and phenylalanine, none of which have normally been demonstrated, make their appearance in the blood.
4) The blood amino acids of the mesenteric vein above the point of ileus are almost unchanged for 6 hours after the establishment of ileus, but after 9 hours glutamine, glycine, glutamic acid, leucine and isoleucine decrease, while asparaginic acid and serine disappear. When the shock stage is reached, alanine, tryptophan, methionine, threonine and cystine all disappear.
5) On the contrary, in the blood of the mesenteric vein below the point of obstruction the amino acids such as leucine and isoleucine increase after 9 hours, but in addition lysine, tyrosine, valine. and phenylalanine not normally present become demonstrable. Furthermore, when the shock stage is reached, not only glutamic acid, glycine, tryptophan, methionine and phenylalanine increase in amount, but arginine, proline and histidine also begin to appear.
(Author's abstract)
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